MYPT1 Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. Expressed in striated muscles, specifically in type 2a fibers (at protein level). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Cellular Component: 
Reference #:  Q9TV77 (UniProtKB)
Alt. Names/Synonyms: 130 kDa regulatory subunit of myosin phosphatase; MYPT1; protein phosphatase 1 regulatory subunit 12A
Gene Symbols: PPP1R12A
Molecular weight: 89,684 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MYPT1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene