Lmr1 a protein kinase kinase of the Lmr family. Predominantly expressed in the nervous system and is involved in neurite extension and apoptosis of cerebellar granule cells. Contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. May be necessary for the induction of growth arrest and/or apoptosis of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes. Four alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Lmr family; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 11|11 E2
Cellular Component:  axonal growth cone; cell projection; cytoplasm; endoplasmic reticulum; integral component of membrane; membrane; perinuclear region of cytoplasm; recycling endosome
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity
Biological Process:  apoptotic process; brain development; negative regulation of axon extension; neuron apoptotic process; peptidyl-tyrosine autophosphorylation; phosphorylation; protein autophosphorylation; protein phosphorylation; Rab protein signal transduction
Reference #:  Q80YE4 (UniProtKB)
Alt. Names/Synonyms: Aatk; AATYK; aatyk1; Apoptosis-associated tyrosine kinase; apoptosis-associated tyrosine kinase 1B; Brain apoptosis-associated tyrosine kinase; Kiaa0641; Lemur tyrosine kinase 1; Lmr1; Lmtk1; mKIAA0641; OTTMUSP00000004389; OTTMUSP00000004391; Serine/threonine-protein kinase LMTK1
Gene Symbols: Aatk
Molecular weight: 144,607 Da
Basal Isoelectric point: 4.45  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below

Lmr1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene