GNRHR Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. Belongs to the G-protein coupled receptor 1 family. Pituitary, ovary, testis, breast and prostate but not in liver and spleen. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 14p21
Cellular Component:  integral component of membrane; integral component of plasma membrane; plasma membrane
Molecular Function:  gonadotropin-releasing hormone receptor activity; growth hormone-releasing hormone receptor activity; protein binding
Biological Process:  cellular response to gonadotropin-releasing hormone; cellular response to hormone stimulus; circadian rhythm; G protein-coupled receptor signaling pathway; negative regulation of cell proliferation
Reference #:  P30969 (UniProtKB)
Alt. Names/Synonyms: GH1; GnRH receptor; GnRH-R; Gnrhr; gonadotropin releasing hormone receptor; Gonadotropin-releasing hormone receptor; growth hormone; Lhrhr
Gene Symbols: Gnrhr
Molecular weight: 37,748 Da
Basal Isoelectric point: 9.68  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene