Kv1.4 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure. Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily. Detected in heart ventricle. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 2 E3|2 56.12 cM
Cellular Component:  asymmetric synapse; axon; cell projection; cell surface; dendritic shaft; dendritic spine; endoplasmic reticulum; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; membrane; plasma membrane; voltage-gated potassium channel complex
Molecular Function:  delayed rectifier potassium channel activity; ion channel activity; potassium channel activity; potassium ion binding; protein binding; voltage-gated ion channel activity; voltage-gated potassium channel activity
Biological Process:  ion transport; potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; regulation of ion transmembrane transport; transmembrane transport
Reference #:  Q61423 (UniProtKB)
Alt. Names/Synonyms: Kcna4; Kv1.4; MGC124445; OTTMUSP00000016013; potassium voltage gated channel, shaker related subfamily, member 4; Potassium voltage-gated channel subfamily A member 4; potassium voltage-gated channel, shaker-related subfamily, member 4; Voltage-gated potassium channel subunit Kv1.4
Gene Symbols: Kcna4
Molecular weight: 73,470 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
Select Structure to View Below

Kv1.4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene