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thrombomodulin
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Endothelial cells are unique in synthesizing thrombomodulin. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 2 G3|2 73.45 cM |
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Cellular Component:
apicolateral plasma membrane; cell surface; external side of plasma membrane; extracellular space; membrane; plasma membrane; serine-type endopeptidase complex; vacuolar membrane
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Molecular Function:
calcium ion binding; transmembrane signaling receptor activity
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Biological Process:
blood coagulation; embryo development; female pregnancy; hemostasis; negative regulation of coagulation
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Reference #:
P15306
(UniProtKB)
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Alt. Names/Synonyms: AI385582; CD141; Fetomodulin; OTTMUSP00000016721; snoRNA MBII-339; Thbd; Thrombomodulin; TM; TRBM
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Gene Symbols: Thbd
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Molecular weight:
61,868 Da
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Basal Isoelectric point:
4.5
Predict pI for various phosphorylation states
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