thrombomodulin Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Endothelial cells are unique in synthesizing thrombomodulin. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2 G3|2 73.45 cM
Cellular Component:  apicolateral plasma membrane; cell surface; extracellular space; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; vacuolar membrane
Molecular Function:  calcium ion binding; transmembrane signaling receptor activity
Biological Process:  blood coagulation; female pregnancy; hemostasis; negative regulation of blood coagulation; negative regulation of coagulation
Reference #:  P15306 (UniProtKB)
Alt. Names/Synonyms: AI385582; CD141; Fetomodulin; OTTMUSP00000016721; snoRNA MBII-339; Thbd; Thrombomodulin; TM; TRBM
Gene Symbols: Thbd
Molecular weight: 61,868 Da
Basal Isoelectric point: 4.5  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene