Fes Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. Widely expressed. Detected in adult colon epithelium (at protein level) (PubMed:16455651, PubMed:19051325). Expressed in melanocytes (at protein level) (PubMed:28463229). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Fer family; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tumor suppressor
Chromosomal Location of human Ortholog: 15q26.1
Cellular Component:  cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; Golgi apparatus; microtubule cytoskeleton
Molecular Function:  ATP binding; immunoglobulin receptor binding; microtubule binding; non-membrane spanning protein tyrosine kinase activity; phosphatidylinositol binding; protein binding; protein tyrosine kinase activity
Biological Process:  cellular response to vitamin D; centrosome cycle; microtubule bundle formation; peptidyl-tyrosine phosphorylation; positive regulation of actin cytoskeleton reorganization; positive regulation of microtubule polymerization; positive regulation of monocyte differentiation; positive regulation of myeloid cell differentiation; positive regulation of neuron projection development; protein autophosphorylation; regulation of cell adhesion; regulation of cell differentiation; regulation of cell motility; regulation of cell proliferation; regulation of cell shape; regulation of mast cell degranulation; regulation of vesicle-mediated transport
Reference #:  P07332 (UniProtKB)
Alt. Names/Synonyms: c-fes/fps protein; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog; feline sarcoma oncogene; Feline sarcoma/Fujinami avian sarcoma oncogene homolog; FES; FES proto-oncogene, tyrosine kinase; FPS; Oncogene FES, feline sarcoma virus; p93c-fes; Proto-oncogene c-Fes; Proto-oncogene c-Fps; proto-oncogene tyrosine-protein kinase Fes/Fps; Tyrosine-protein kinase Fes/Fps
Gene Symbols: FES
Molecular weight: 93,497 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein