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PASK
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; CAMKL family; EC 2.7.11.1; Kinase, protein; PASK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 1|1 D |
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Cellular Component:
cytoplasm; cytosol; intracellular anatomical structure; nucleus
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Molecular Function:
ATP binding; kinase activity; lipid binding; nucleotide binding; phosphatidylinositol binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
energy homeostasis; intracellular signal transduction; negative regulation of glycogen biosynthetic process; phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of glucagon secretion; regulation of respiratory gaseous exchange
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Reference #:
Q8CEE6
(UniProtKB)
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Alt. Names/Synonyms: Kiaa0135; mKIAA0135; OTTMUSP00000024404; PAS domain containing serine/threonine kinase; PAS domain-containing serine/threonine-protein kinase; PAS-kinase; Pask; PASKIN
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Gene Symbols: Pask
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Molecular weight:
151,250 Da
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Basal Isoelectric point:
4.96
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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