SYT6 May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm. Belongs to the synaptotagmin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 2q34
Cellular Component:  cell junction; cytosol; exocytic vesicle; extrinsic component of membrane; glutamatergic synapse; integral component of membrane; integral component of synaptic membrane; perinuclear endoplasmic reticulum; plasma membrane; synaptic vesicle membrane
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; clathrin binding; identical protein binding; phosphatidylserine binding; protein heterodimerization activity; protein homodimerization activity; SNARE binding; syntaxin binding
Biological Process:  acrosomal vesicle exocytosis; acrosome reaction; calcium ion regulated exocytosis; cellular response to calcium ion; presynaptic dense core vesicle exocytosis; regulation of calcium ion-dependent exocytosis; regulation of dopamine secretion; vesicle-mediated transport
Reference #:  Q62746 (UniProtKB)
Alt. Names/Synonyms: MGC116356; synaptotagmin 6; Synaptotagmin VI; Synaptotagmin-6; Syt6; SytVI
Gene Symbols: Syt6
Molecular weight: 57,179 Da
Basal Isoelectric point: 8.12  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene