CDP138 Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 6|6 G3
Cellular Component:  cell cortex; cell projection; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; membrane; microtubule organizing center; plasma membrane; ruffle membrane
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding; lipid binding
Biological Process:  cellular response to insulin stimulus; insulin receptor signaling pathway via phosphatidylinositol 3-kinase; intracellular protein transmembrane transport; positive regulation of glucose import; positive regulation of glucose transmembrane transport; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein localization to plasma membrane; protein transport; vesicle fusion
Reference #:  Q7TPS5 (UniProtKB)
Alt. Names/Synonyms: 5730419I09Rik; C030008B15Rik; C2 domain-containing protein 5; hypothetical protein LOC74741; K0528; Kiaa0528; RIKEN cDNA 5730419I09 gene; Uncharacterized protein KIAA0528
Gene Symbols: Kiaa0528
Molecular weight: 111,664 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
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CDP138

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene