TSSK4 Serine/threonine kinase which is involved in male germ cell development and in mature sperm function. May be involved in the Cre/Creb signaling pathway. Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells. Phosphorylates CREM on 'Ser-116' in vitro. Phosphorylates ODF2 on 'Ser-95'. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Expressed only in the testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); TSSK family
Chromosomal Location of Human Ortholog: 14|14 C3
Cellular Component:  acrosomal vesicle; cell projection; cilium; cytoplasm; cytoplasmic vesicle; motile cilium; nucleus; sperm flagellum
Molecular Function:  ATP binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; transferase activity
Biological Process:  cell differentiation; fertilization; intracellular signal transduction; multicellular organism development; peptidyl-serine phosphorylation; peptidyl-threonine autophosphorylation; phosphorylation; positive regulation of CREB transcription factor activity; protein phosphorylation; spermatid development; spermatogenesis
Reference #:  Q9D411 (UniProtKB)
Alt. Names/Synonyms: 1700020B19Rik; 4933424F08Rik; Testis-specific kinase 4; testis-specific serine kinase 4; testis-specific serine/threonine protein kinase 5 variant alpha; testis-specific serine/threonine protein kinase 5 variant beta; testis-specific serine/threonine protein kinase 5 variant delta; testis-specific serine/threonine protein kinase 5 variant gamma; Testis-specific serine/threonine-protein kinase 4; TSK-4; TSSK-4; Tssk4; Tssk5
Gene Symbols: Tssk4
Molecular weight: 37,377 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene