NUMB Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. Interacts with CDH1 and TFAP2B. Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: 6q24
Cellular Component:  apical part of cell; basolateral plasma membrane; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; early endosome; extrinsic component of plasma membrane; glutamatergic synapse; membrane; nucleus; postsynaptic density
Molecular Function:  alpha-catenin binding; beta-catenin binding; cadherin binding; protein binding
Biological Process:  adherens junction organization; axonogenesis; cell differentiation; cell proliferation; forebrain development; lateral ventricle development; lung epithelial cell differentiation; negative regulation of Notch signaling pathway; negative regulation of protein localization to plasma membrane; nervous system development; neuroblast division in subventricular zone; neuroblast proliferation; positive regulation of cell migration; positive regulation of dendrite morphogenesis; positive regulation of neurogenesis; positive regulation of polarized epithelial cell differentiation; regulation of neuron differentiation; regulation of postsynaptic neurotransmitter receptor internalization; regulation of postsynaptic specialization assembly
Reference #:  Q2LC84 (UniProtKB)
Alt. Names/Synonyms: MGC188364; Numb; numb gene homolog; numb homolog; numb homolog (Drosophila); Numb isoform i/i; Protein numb homolog
Gene Symbols: Numb
Molecular weight: 70,596 Da
Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NUMB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept