NUMB Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: 12|12 D1
Cellular Component:  apical part of cell; basolateral plasma membrane; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; early endosome; extrinsic component of plasma membrane; glutamatergic synapse; membrane; nucleus; postsynaptic density
Molecular Function:  alpha-catenin binding; beta-catenin binding; cadherin binding; protein binding
Biological Process:  adherens junction organization; axonogenesis; forebrain development; lateral ventricle development; lung epithelial cell differentiation; multicellular organism development; negative regulation of Notch signaling pathway; negative regulation of protein localization to plasma membrane; nervous system development; neuroblast division in subventricular zone; neuroblast proliferation; positive regulation of cell migration; positive regulation of dendrite morphogenesis; positive regulation of neurogenesis; positive regulation of polarized epithelial cell differentiation; regulation of neuron differentiation; regulation of postsynaptic neurotransmitter receptor internalization; regulation of postsynaptic specialization assembly
Reference #:  Q9QZS3 (UniProtKB)
Alt. Names/Synonyms: m-Nb; m-num; m-Numb; mnb; Numb; NUMB endocytic adaptor protein; numb gene homolog; numb gene homolog (Drosophila); numb homolog; Protein numb homolog
Gene Symbols: Numb
Molecular weight: 70,813 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene