NUMB Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of human Ortholog: 14q24.2-q24.3
Cellular Component:  apical part of cell; basolateral plasma membrane; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; early endosome; endosome membrane; glutamatergic synapse; plasma membrane
Molecular Function:  alpha-catenin binding; beta-catenin binding; protein binding
Biological Process:  adherens junction organization; axonogenesis; lateral ventricle development; negative regulation of protein localization to plasma membrane; neuroblast division in subventricular zone; positive regulation of cell migration; positive regulation of neurogenesis; regulation of postsynaptic neurotransmitter receptor internalization
Reference #:  P49757 (UniProtKB)
Alt. Names/Synonyms: c14_5527; C14orf41; h-Numb; NUMB; NUMB endocytic adaptor protein; numb homolog; numb homolog (Drosophila); Protein numb homolog; Protein S171; S171
Gene Symbols: NUMB
Molecular weight: 70,804 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein