NUMBL Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of mouse Ortholog: 7|7 A3
Cellular Component:  cytoplasm
Biological Process:  adherens junction organization; axonogenesis; cytokine-mediated signaling pathway; forebrain development; lateral ventricle development; multicellular organism development; nervous system development; neuroblast division in subventricular zone; neuroblast proliferation; positive regulation of dendrite morphogenesis; positive regulation of neurogenesis; protein metabolic process
Reference #:  O08919 (UniProtKB)
Alt. Names/Synonyms: Nbl; numb-like; Numb-like protein; Numbl; OTTMUSP00000028115
Gene Symbols: Numbl
Molecular weight: 64,130 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene