NUMBL Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. Interacts (via PTB domain) with MAP3K7IP2 (via C- terminal). Interacts (via C-terminal) with TRAF6 (via TRAF domains). Associates with EPS15 and NOTCH1. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component:  cytoplasm
Molecular Function:  protein binding
Biological Process:  axonogenesis; cytokine-mediated signaling pathway; lateral ventricle development; nervous system development; neuroblast division in subventricular zone; positive regulation of neurogenesis; protein metabolic process
Reference #:  Q9Y6R0 (UniProtKB)
Alt. Names/Synonyms: CAG3A; CTG3a; NBL; numb homolog (Drosophila)-like; numb homolog-like; Numb-like protein; Numb-R; Numb-related protein; NUMBL; NUMBLIKE; NUMBR; TNRC23
Gene Symbols: NUMBL
Molecular weight: 64,891 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
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NUMBL

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene