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CTDSP1
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 2q35 |
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Cellular Component:
nucleoplasm; nucleus
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Molecular Function:
metal ion binding; myosin phosphatase activity; protein binding; RNA polymerase II CTD heptapeptide repeat phosphatase activity
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Biological Process:
negative regulation of G1/S transition of mitotic cell cycle; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of protein phosphorylation; protein dephosphorylation; regulation of transcription by RNA polymerase II
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Reference #:
Q9GZU7
(UniProtKB)
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Alt. Names/Synonyms: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; CTD small phosphatase 1; CTDS1; CTDSP1; NIF3; NLI-IF; NLI-interacting factor 3; NLIIF; Nuclear LIM interactor-interacting factor 3; SCP1; Small C-terminal domain phosphatase 1; Small CTD phosphatase 1
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Gene Symbols: CTDSP1
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Molecular weight:
29,203 Da
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Basal Isoelectric point:
5.62
Predict pI for various phosphorylation states
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