CTDSP1 Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 2q35
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  metal ion binding; protein binding; RNA polymerase II CTD heptapeptide repeat phosphatase activity
Biological Process:  negative regulation of G1/S transition of mitotic cell cycle; negative regulation of neuron differentiation; negative regulation of protein phosphorylation; protein dephosphorylation; regulation of transcription by RNA polymerase II
Reference #:  Q9GZU7 (UniProtKB)
Alt. Names/Synonyms: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; CTD small phosphatase 1; CTDS1; CTDSP1; NIF3; NLI-IF; NLI-interacting factor 3; NLIIF; Nuclear LIM interactor-interacting factor 3; SCP1; Small C-terminal domain phosphatase 1; Small CTD phosphatase 1
Gene Symbols: CTDSP1
Molecular weight: 29,203 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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