DNAJA3 Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial
Chromosomal Location of human Ortholog: 16p13.3
Cellular Component:  actin filament; cytoplasmic side of plasma membrane; cytosol; intracellular membrane-bounded organelle; mitochondrial matrix; mitochondrion; neuromuscular junction; nucleus; postsynaptic membrane
Molecular Function:  ATP binding; GTPase regulator activity; Hsp70 protein binding; metal ion binding; protein binding; protein kinase binding; unfolded protein binding
Biological Process:  activation-induced cell death of T cells; cellular senescence; mitochondrial DNA replication; mitochondrion organization; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of transcription by RNA polymerase II; positive regulation of T cell proliferation; protein folding; response to heat; skeletal muscle acetylcholine-gated channel clustering; small GTPase mediated signal transduction; T cell differentiation in thymus
Reference #:  Q96EY1 (UniProtKB)
Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily A, member 3; DnaJ heat shock protein family (Hsp40) member A3; DnaJ homolog subfamily A member 3, mitochondrial; DnaJ protein Tid-1; DNAJA3; DNJA3; FLJ45758; HCA57; Hepatocellular carcinoma-associated antigen 57; hTid-1; TID1; tumorous imaginal discs homolog; Tumorous imaginal discs protein Tid56 homolog
Gene Symbols: DNAJA3
Molecular weight: 52,489 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein