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DNAJA3
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial |
| Chromosomal Location of Human Ortholog: 16p13.3 |
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Cellular Component:
cell junction; cytosol; extrinsic component of plasma membrane; intracellular membrane-bounded organelle; mitochondrial matrix; mitochondrion; neuromuscular junction; nucleus; postsynaptic membrane
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Molecular Function:
ATP binding; GTPase regulator activity; Hsp70 protein binding; metal ion binding; protein binding; unfolded protein binding
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Biological Process:
activation-induced cell death of T cells; cell aging; mitochondrial DNA replication; negative regulation of cell proliferation; negative regulation of programmed cell death; negative regulation of transcription by RNA polymerase II; positive regulation of T cell proliferation; protein folding; regulation of catalytic activity; response to heat; skeletal muscle acetylcholine-gated channel clustering; small GTPase mediated signal transduction; T cell differentiation in thymus
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Reference #:
Q96EY1
(UniProtKB)
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Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily A, member 3; DnaJ homolog subfamily A member 3, mitochondrial; DnaJ protein Tid-1; DNAJA3; DNJA3; FLJ45758; HCA57; Hepatocellular carcinoma-associated antigen 57; hTid-1; TID1; tumorous imaginal discs homolog; Tumorous imaginal discs protein Tid56 homolog
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Gene Symbols: DNAJA3
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Molecular weight:
52,489 Da
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Basal Isoelectric point:
9.37
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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