RAB27A Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Belongs to the small GTPase superfamily. Rab family. Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 15q21.3
Cellular Component:  apical plasma membrane; cytosol; dendrite; exocytic vesicle; extracellular region; Golgi apparatus; late endosome; lysosome; melanosome; melanosome membrane; multivesicular body membrane; photoreceptor outer segment; secretory granule membrane; specific granule lumen; synapse; Weibel-Palade body
Molecular Function:  GDP binding; GTP binding; GTPase activity; myosin V binding; protein binding; protein domain specific binding
Biological Process:  antigen processing and presentation; blood coagulation; complement-dependent cytotoxicity; cytotoxic T cell degranulation; exocytosis; exosomal secretion; melanocyte differentiation; melanosome localization; melanosome transport; multivesicular body organization; multivesicular body sorting pathway; natural killer cell degranulation; neutrophil degranulation; positive regulation of constitutive secretory pathway; positive regulation of exocytosis; positive regulation of gene expression; positive regulation of phagocytosis; positive regulation of reactive oxygen species biosynthetic process; positive regulation of regulated secretory pathway; protein targeting; synaptic vesicle transport
Disease: Griscelli Syndrome, Type 2
Reference #:  P51159 (UniProtKB)
Alt. Names/Synonyms: GS2; GTP-binding protein Ram; HsT18676; MGC117246; mutant Ras-related protein Rab-27A; Rab-27; RAB27; RAB27A; RAB27A, member RAS oncogene family; RAM; Ras-related protein Rab-27A; RB27A
Gene Symbols: RAB27A
Molecular weight: 24,868 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB