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UBE2J1
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Belongs to the ubiquitin-conjugating enzyme family. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.19; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of mouse Ortholog: 4|4 A5 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; membrane; nucleus
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Molecular Function:
ATP binding; nucleotide binding; transferase activity; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding
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Biological Process:
negative regulation of retrograde protein transport, ER to cytosol; protein N-linked glycosylation via asparagine; protein polyubiquitination; regulation of macrophage cytokine production; regulation of tumor necrosis factor production; spermatid development; ubiquitin-dependent ERAD pathway
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Reference #:
Q9JJZ4
(UniProtKB)
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Alt. Names/Synonyms: 0710008M05Rik; 1110030I22Rik; E2 ubiquitin-conjugating enzyme J1; Ncub; Ncube; NCUBE-1; Ncube1; non-canonical ubiquitin conjugating enzyme 1; Non-canonical ubiquitin-conjugating enzyme 1; OTTMUSP00000005183; UB2J1; Ubc6; Ubc6p; Ube2j1; Ubiquitin-conjugating enzyme E2 J1; ubiquitin-conjugating enzyme E2, J1; ubiquitin-conjugating enzyme E2J 1
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Gene Symbols: Ube2j1
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Molecular weight:
34,990 Da
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Basal Isoelectric point:
6.51
Predict pI for various phosphorylation states
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