UBE2J1 Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Belongs to the ubiquitin-conjugating enzyme family. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 6q15
Cellular Component:  endoplasmic reticulum membrane; integral component of membrane
Molecular Function:  ATP binding; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding
Biological Process:  negative regulation of retrograde protein transport, ER to cytosol; protein N-linked glycosylation via asparagine; protein ubiquitination; regulation of tumor necrosis factor biosynthetic process; spermatid development; ubiquitin-dependent ERAD pathway
Reference #:  Q9Y385 (UniProtKB)
Alt. Names/Synonyms: CGI-76; E2 ubiquitin-conjugating enzyme J1; HSPC153; HSPC205; HSU93243; HsUBC6e; MGC12555; NCUBE-1; NCUBE1; Non-canonical ubiquitin-conjugating enzyme 1; non-canonical ubquitin conjugating enzyme 1; UB2J1; UBC6; UBC6E; Ubc6p; UBE2J1; ubiquitin conjugating enzyme E2 J1; Ubiquitin-conjugating enzyme E2 J1; ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast); ubiquitin-conjugating enzyme E2, J1, U; Yeast ubiquitin-conjugating enzyme UBC6 homolog E
Gene Symbols: UBE2J1
Molecular weight: 35,199 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
Select Structure to View Below

UBE2J1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene