SPINK5 Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5q32
Cellular Component:  cell cortex; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; epidermal lamellar body; extracellular region; intracellular membrane-bounded organelle; perinuclear region of cytoplasm
Molecular Function:  serine-type endopeptidase inhibitor activity
Biological Process:  cornification; epidermal cell differentiation; epithelial cell differentiation; extracellular matrix organization; hair cell differentiation; negative regulation of angiogenesis; negative regulation of antibacterial peptide production; negative regulation of immune response; negative regulation of serine-type endopeptidase activity; regulation of cell adhesion; regulation of T cell differentiation; regulation of timing of anagen
Disease: Netherton Syndrome
Reference #:  Q9NQ38 (UniProtKB)
Alt. Names/Synonyms: DKFZp686K19184; FLJ21544; FLJ97536; FLJ97596; FLJ99794; Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665; ISK5; LEKTI; LETKI; Lympho-epithelial Kazal-type-related inhibitor; lymphoepithelial Kazal-type-related inhibitor; NETS; NS; serine peptidase inhibitor Kazal type 5; serine peptidase inhibitor, Kazal type 5; Serine protease inhibitor Kazal-type 5; serine protease inhibitor, Kazal type 5; SPINK5; VAKTI
Gene Symbols: SPINK5
Molecular weight: 120,714 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein