SAC3 The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.-
Chromosomal Location of human Ortholog: 6q21
Cellular Component:  early endosome membrane; endosome membrane; Golgi membrane; intracellular membrane-bounded organelle; late endosome membrane; lipid droplet; recycling endosome
Molecular Function:  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; phosphatidylinositol-3-phosphate phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; phosphatidylinositol-4-phosphate phosphatase activity; protein binding; protein serine/threonine phosphatase activity
Biological Process:  locomotory behavior; myelin assembly; negative regulation of myelination; neuron development; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; pigmentation; positive regulation of neuron projection development; vacuole organization
Disease: Amyotrophic Lateral Sclerosis 11; Charcot-marie-tooth Disease, Type 4j; Polymicrogyria, Bilateral Temporooccipital; Yunis-varon Syndrome
Reference #:  Q92562 (UniProtKB)
Alt. Names/Synonyms: ALS11; BTOP; CMT4J; dJ249I4.1; FIG4; FIG4 homolog, SAC domain containing lipid phosphatase; FIG4 homolog, SAC1 domain containing lipid phosphatase; FIG4 homolog, SAC1 lipid phosphatase domain containing; FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae); FIG4 phosphoinositide 5-phosphatase; hSac3; KIAA0274; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; Polyphosphoinositide phosphatase; Sac domain-containing inositol phosphatase 3; SAC domain-containing protein 3; SAC3; YVS
Gene Symbols: FIG4
Molecular weight: 103,635 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein