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RAD54L
Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments. May play also an essential role in telomere length maintenance and telomere capping in mammalian cells. Belongs to the SNF2/RAD54 helicase family. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; DNA repair, damage; EC 3.6.1.-; EC 3.6.4.-; Helicase |
| Chromosomal Location of Human Ortholog: 4|4 D1 |
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Cellular Component:
nucleoplasm; nucleus; protein-containing complex
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Molecular Function:
annealing helicase activity; ATP binding; DNA binding; helicase activity; hydrolase activity; nucleotide binding
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Biological Process:
cellular response to DNA damage stimulus; chromosome organization; determination of adult lifespan; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; response to drug; response to ionizing radiation
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Reference #:
P70270
(UniProtKB)
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Alt. Names/Synonyms: DNA repair and recombination protein RAD54-like; mHR54; mRAD54; OTTMUSP00000008902; OTTMUSP00000008903; RAD; Rad54; RAD54 homolog; RAD54 like (S. cerevisiae); Rad54l
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Gene Symbols: Rad54l
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Molecular weight:
84,694 Da
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Basal Isoelectric point:
8.89
Predict pI for various phosphorylation states
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