RAD54L Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments. May play also an essential role in telomere length maintenance and telomere capping in mammalian cells. Belongs to the SNF2/RAD54 helicase family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; DNA repair, damage; EC 3.6.1.-; EC 3.6.4.-; Helicase
Chromosomal Location of human Ortholog: 1p34.1
Cellular Component:  nucleoplasm; nucleus; protein-containing complex
Molecular Function:  ATP binding; ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; ATP-dependent DNA/DNA annealing activity; DNA translocase activity; helicase activity; metal ion binding; protein binding
Biological Process:  chromatin remodeling; chromosome organization; determination of adult lifespan; DNA recombination; DNA repair; double-strand break repair via synthesis-dependent strand annealing; meiotic cell cycle; reciprocal meiotic recombination; response to ionizing radiation; response to xenobiotic stimulus
Disease: Breast Cancer; Lymphoma, Non-hodgkin, Familial
Reference #:  Q92698 (UniProtKB)
Alt. Names/Synonyms: DNA repair and recombination protein RAD54-like; hHR54; HR54; hRAD54; RAD54; RAD54 homolog; RAD54 like; RAD54-like (S. cerevisiae); RAD54A; RAD54L
Gene Symbols: RAD54L
Molecular weight: 84,352 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RAD54L

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein