PSMA1 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Belongs to the peptidase T1A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 7 F1|7 59.32 cM
Cellular Component:  centrosome; cytoplasm; nucleoplasm; nucleus; proteasome complex; proteasome core complex; proteasome core complex, alpha-subunit complex
Molecular Function:  endopeptidase activity; hydrolase activity; lipopolysaccharide binding; peptidase activity; protein binding; threonine-type endopeptidase activity
Biological Process:  immune system process; negative regulation of inflammatory response to antigenic stimulus; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; proteolysis; proteolysis involved in cellular protein catabolic process; ubiquitin-dependent protein catabolic process
Reference #:  Q9R1P4 (UniProtKB)
Alt. Names/Synonyms: 20S proteasome subunit C2; alpha-type; C2; HC2; Macropain subunit C2; Multicatalytic endopeptidase complex subunit C2; OTTMUSP00000030740; Pro; Pros-30; proteasome (prosome, macropain) subunit, alpha type 1; Proteasome component C2; Proteasome nu chain; proteasome subunit alpha 1; Proteasome subunit alpha type-1; PSA1; Psma1
Gene Symbols: Psma1
Molecular weight: 29,547 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene