POLB Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Belongs to the DNA polymerase type-X family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; DNA replication; EC; Lyase; Transferase
Chromosomal Location of human Ortholog: 8p11.21
Cellular Component:  cytoplasm; microtubule; nucleoplasm; nucleus; protein-containing complex; spindle microtubule
Molecular Function:  damaged DNA binding; DNA-(apurinic or apyrimidinic site) endonuclease activity; DNA-directed DNA polymerase activity; enzyme binding; lyase activity; metal ion binding; microtubule binding; protein binding
Biological Process:  aging; base-excision repair; base-excision repair, gap-filling; cellular response to DNA damage stimulus; DNA biosynthetic process; DNA repair; DNA-templated DNA replication; double-strand break repair via nonhomologous end joining; homeostasis of number of cells; immunoglobulin heavy chain V-D-J recombination; in utero embryonic development; inflammatory response; intrinsic apoptotic signaling pathway in response to DNA damage; lymph node development; neuron apoptotic process; nucleotide-excision repair, DNA gap filling; pyrimidine dimer repair; response to ethanol; response to gamma radiation; response to hyperoxia; salivary gland morphogenesis; somatic hypermutation of immunoglobulin genes; spleen development
Reference #:  P06746 (UniProtKB)
Alt. Names/Synonyms: DNA pol beta; DNA polymerase beta; DNA polymerase beta subunit; DNA-directed DNA polymerase beta; DPOLB; MGC125976; POLB; polymerase (DNA directed), beta; polymerase (DNA) beta
Gene Symbols: POLB
Molecular weight: 38,178 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.