CXXC1 Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component:  cytosol; histone methyltransferase complex; nuclear matrix; nuclear speck; nucleoplasm; nucleus; Set1C/COMPASS complex
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; proximal promoter sequence-specific DNA binding; unmethylated CpG binding; zinc ion binding
Biological Process:  histone H3-K4 methylation; IRE1-mediated unfolded protein response; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  Q9P0U4 (UniProtKB)
Alt. Names/Synonyms: 2410002I16Rik; 5830420C16Rik; CFP1; CGBP; CpG binding protein; CpG-binding protein; CXXC finger 1 (PHD domain); CXXC-type zinc finger protein 1; CXXC1; DNA-binding protein with PHD finger and CXXC domain; hCGBP; HsT2645; PCCX1; PHD finger and CXXC domain-containing protein 1; PHF18; SPP1; ZCGPC1; zinc finger, CpG binding-type containing 1
Gene Symbols: CXXC1
Molecular weight: 75,712 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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