PEX16 Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. Belongs to the peroxin-16 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; integral component of peroxisomal membrane; peroxisome
Molecular Function:  protein binding; protein C-terminus binding
Biological Process:  ER-dependent peroxisome localization; ER-dependent peroxisome organization; peroxisome membrane biogenesis; peroxisome organization; protein import into peroxisome matrix; protein import into peroxisome membrane; protein targeting to peroxisome; protein to membrane docking
Disease: Peroxisome Biogenesis Disorder 8a (zellweger); Peroxisome Biogenesis Disorder 8b
Reference #:  Q9Y5Y5 (UniProtKB)
Alt. Names/Synonyms: PBD8A; PBD8B; peroxin 16; Peroxin-16; Peroxisomal biogenesis factor 16; Peroxisomal membrane protein PEX16; peroxisome biogenesis factor 16; PEX16
Gene Symbols: PEX16
Molecular weight: 38,629 Da
Basal Isoelectric point: 9.85  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein