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NEBL
Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion. Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines in cardiac cells and to dense bodies in nonmuscle cells. Isoform 2 is expressed in non-muscle cells such as in fibroblasts. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding |
| Chromosomal Location of human Ortholog: 10p12.31 |
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Cellular Component:
I band; stress fiber; Z disc
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Molecular Function:
actin filament binding; cytoskeletal protein binding; filamin binding; protein binding; structural constituent of muscle; tropomyosin binding
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Biological Process:
cardiac muscle thin filament assembly
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Reference #:
O76041
(UniProtKB)
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Alt. Names/Synonyms: Actin-binding Z-disk protein; bA165O3.1; C10orf113; FLJ53769; LASP2; LIM and SH3 protein 2; LIM-nebulette; LNEBL; MGC119746; MGC119747; NEBL; Nebulette
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Gene Symbols: NEBL
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Molecular weight:
116,453 Da
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Basal Isoelectric point:
7.89
Predict pI for various phosphorylation states
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