|
NEBL
Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion. Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines in cardiac cells and to dense bodies in nonmuscle cells. Isoform 2 is expressed in non-muscle cells such as in fibroblasts. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Actin-binding |
| Chromosomal Location of Human Ortholog: 10p12.31 |
|
Cellular Component:
I band; stress fiber; Z disc
|
|
Molecular Function:
actin filament binding; cytoskeletal protein binding; filamin binding; protein binding; structural constituent of muscle; tropomyosin binding
|
|
Biological Process:
cardiac muscle thin filament assembly
|
|
Reference #:
O76041
(UniProtKB)
|
|
Alt. Names/Synonyms: Actin-binding Z-disk protein; bA165O3.1; C10orf113; FLJ53769; LASP2; LIM and SH3 protein 2; LIM-nebulette; LNEBL; MGC119746; MGC119747; NEBL; Nebulette
|
|
Gene Symbols: NEBL
|
|
Molecular weight:
116,453 Da
|
|
Basal Isoelectric point:
7.89
Predict pI for various phosphorylation states
|
