NEBL Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion. Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines in cardiac cells and to dense bodies in nonmuscle cells. Isoform 2 is expressed in non-muscle cells such as in fibroblasts. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding
Chromosomal Location of human Ortholog: 10p12.31
Cellular Component:  I band; stress fiber; Z disc
Molecular Function:  actin filament binding; cytoskeletal protein binding; filamin binding; protein binding; structural constituent of muscle; tropomyosin binding
Biological Process:  cardiac muscle thin filament assembly
Reference #:  O76041 (UniProtKB)
Alt. Names/Synonyms: Actin-binding Z-disk protein; bA165O3.1; C10orf113; FLJ53769; LASP2; LIM and SH3 protein 2; LIM-nebulette; LNEBL; MGC119746; MGC119747; NEBL; Nebulette
Gene Symbols: NEBL
Molecular weight: 116,453 Da
Basal Isoelectric point: 7.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene