NDUFB8 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I NDUFB8 subunit family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.6.5.3; EC 1.6.99.3; Endoplasmic reticulum; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 10q24.31
Cellular Component:  endoplasmic reticulum; integral component of membrane; mitochondrial inner membrane; mitochondrial matrix; mitochondrial respiratory chain complex I; mitochondrion
Molecular Function:  NADH dehydrogenase (ubiquinone) activity
Biological Process:  mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly
Disease: Mitochondrial Complex I Deficiency, Nuclear Type 32
Reference #:  O95169 (UniProtKB)
Alt. Names/Synonyms: ASHI; CI-ASHI; complex I ASHI subunit; Complex I-ASHI; MC1DN32; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; NADH-ubiquinone oxidoreductase ASHI subunit; NADH:ubiquinone oxidoreductase ASHI subunit; NADH:ubiquinone oxidoreductase subunit B8; NDUB8; NDUFB8
Gene Symbols: NDUFB8
Molecular weight: 21,766 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
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NDUFB8

Protein Structure Not Found.


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