|
NDUFB8
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I NDUFB8 subunit family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 1.6.5.3; EC 1.6.99.3; Endoplasmic reticulum; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase |
| Chromosomal Location of human Ortholog: 10q24.31 |
|
Cellular Component:
endoplasmic reticulum; mitochondrial inner membrane; mitochondrial matrix; mitochondrial respiratory chain complex I; mitochondrion
|
|
Molecular Function:
NADH dehydrogenase (ubiquinone) activity
|
|
Biological Process:
aerobic respiration; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; proton motive force-driven mitochondrial ATP synthesis
|
|
Disease: Mitochondrial Complex I Deficiency, Nuclear Type 32
|
|
Reference #:
O95169
(UniProtKB)
|
|
Alt. Names/Synonyms: ASHI; CI-ASHI; complex I ASHI subunit; Complex I-ASHI; MC1DN32; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; NADH-ubiquinone oxidoreductase ASHI subunit; NADH:ubiquinone oxidoreductase ASHI subunit; NADH:ubiquinone oxidoreductase subunit B8; NDUB8; NDUFB8
|
|
Gene Symbols: NDUFB8
|
|
Molecular weight:
21,766 Da
|
|
Basal Isoelectric point:
6.29
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
