MYO1D Unconventional myosin that functions as actin-based motor protein with ATPase activity. Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes. Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Expressed in many tissues. Highest levels in brain, followed by lung and ovary; expression is lowest in spleen. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component:  apical dendrite; axolemma; axon; basolateral plasma membrane; brush border; cell cortex; cytoplasmic vesicle; cytosol; early endosome; endosome; myelin sheath; myosin complex; neuron projection; neuronal cell body; perikaryon; plasma membrane raft; smooth endoplasmic reticulum
Molecular Function:  actin filament binding; actin-dependent ATPase activity; ATP binding; calcium-dependent protein binding; calmodulin binding; microfilament motor activity; protein domain specific binding
Biological Process:  cellular localization; early endosome to recycling endosome transport; forebrain development; negative regulation of phosphatase activity; protein transport
Reference #:  O94832 (UniProtKB)
Alt. Names/Synonyms: KIAA0727; MYO1D; myosin ID; myosin-I gamma; Myosin-Id; myr4; PPP1R108; protein phosphatase 1, regulatory subunit 108; Unconventional myosin-Id
Gene Symbols: MYO1D
Molecular weight: 116,202 Da
Basal Isoelectric point: 9.44  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene