KIF18A Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. Belongs to the kinesin-like protein family. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 11p14.1
Cellular Component:  caveola; cytoplasm; cytosol; kinetochore; kinetochore microtubule; microtubule cytoskeleton; microtubule organizing center; nucleus; ruffle
Molecular Function:  actin binding; ATP binding; ATP-dependent microtubule motor activity, plus-end-directed; microtubule binding; microtubule plus-end binding; protein binding; tubulin-dependent ATPase activity
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; cellular response to estradiol stimulus; male meiotic nuclear division; microtubule depolymerization; microtubule-based movement; mitotic metaphase plate congression; protein transport; regulation of microtubule cytoskeleton organization; retrograde vesicle-mediated transport, Golgi to ER; seminiferous tubule development
Reference #:  Q8NI77 (UniProtKB)
Alt. Names/Synonyms: DKFZp434G2226; KI18A; KIF18A; kinesin family member 18A; Kinesin-like protein KIF18A; Marrow stromal KIF18A; MS-KIF18A
Gene Symbols: KIF18A
Molecular weight: 102,281 Da
Basal Isoelectric point: 9.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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