KIF18A Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of human Ortholog: 11p14.1
Cellular Component:  caveola; cytoplasm; cytosol; kinesin complex; kinetochore; kinetochore microtubule; microtubule; microtubule cytoskeleton; microtubule organizing center; mitotic spindle astral microtubule; mitotic spindle midzone; nucleus; ruffle
Molecular Function:  actin binding; ATP binding; ATP hydrolysis activity; microtubule binding; microtubule motor activity; microtubule plus-end binding; plus-end-directed microtubule motor activity; protein binding; tubulin-dependent ATPase activity
Biological Process:  cellular response to estradiol stimulus; male meiotic nuclear division; microtubule depolymerization; microtubule-based movement; mitotic metaphase plate congression; mitotic sister chromatid segregation; protein transport; regulation of microtubule cytoskeleton organization; seminiferous tubule development
Reference #:  Q8NI77 (UniProtKB)
Alt. Names/Synonyms: DKFZp434G2226; KI18A; KIF18A; kinesin family member 18A; Kinesin-like protein KIF18A; Marrow stromal KIF18A; MS-KIF18A; PPP1R99; protein phosphatase 1, regulatory subunit 99
Gene Symbols: KIF18A
Molecular weight: 102,281 Da
Basal Isoelectric point: 9.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene