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KIF18A
Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Motor |
| Chromosomal Location of human Ortholog: 11p14.1 |
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Cellular Component:
caveola; cytoplasm; cytosol; kinesin complex; kinetochore; kinetochore microtubule; microtubule; microtubule cytoskeleton; microtubule organizing center; mitotic spindle astral microtubule; mitotic spindle midzone; nucleus; ruffle
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Molecular Function:
actin binding; ATP binding; ATP hydrolysis activity; microtubule binding; microtubule motor activity; microtubule plus-end binding; plus-end-directed microtubule motor activity; protein binding; tubulin-dependent ATPase activity
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Biological Process:
cellular response to estradiol stimulus; male meiotic nuclear division; microtubule depolymerization; microtubule-based movement; mitotic metaphase plate congression; mitotic sister chromatid segregation; protein transport; regulation of microtubule cytoskeleton organization; seminiferous tubule development
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Reference #:
Q8NI77
(UniProtKB)
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Alt. Names/Synonyms: DKFZp434G2226; KI18A; KIF18A; kinesin family member 18A; Kinesin-like protein KIF18A; Marrow stromal KIF18A; MS-KIF18A; PPP1R99; protein phosphatase 1, regulatory subunit 99
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Gene Symbols: KIF18A
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Molecular weight:
102,281 Da
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Basal Isoelectric point:
9.09
Predict pI for various phosphorylation states
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