CASK Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Belongs to the MAGUK family. Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; CAMK group; CASK family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: Xp11.4
Cellular Component:  actin cytoskeleton; basement membrane; basolateral plasma membrane; cell-cell junction; ciliary membrane; cytoplasm; cytosol; nuclear lamina; nuclear matrix; nucleolus; plasma membrane; presynaptic membrane; Schaffer collateral - CA1 synapse; vesicle
Molecular Function:  ATP binding; calmodulin binding; guanylate kinase activity; neurexin family protein binding; protein binding; protein serine/threonine kinase activity
Biological Process:  calcium ion import; cell adhesion; GDP metabolic process; GMP metabolic process; negative regulation of cell-matrix adhesion; negative regulation of cellular response to growth factor stimulus; negative regulation of keratinocyte proliferation; negative regulation of wound healing; neurotransmitter secretion; positive regulation of calcium ion import; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of synaptic vesicle exocytosis
Disease: Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency; Fg Syndrome 4; Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia
Reference #:  O14936 (UniProtKB)
Alt. Names/Synonyms: CAGH39; calcium/calmodulin dependent serine protein kinase; calcium/calmodulin-dependent serin protein kinase; Calcium/calmodulin-dependent serine protein kinase; calcium/calmodulin-dependent serine protein kinase (MAGUK family); calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase; CAMGUK; CASK; CMG; CSKP; FGS4; FLJ22219; FLJ31914; hCASK; LIN2; MICPCH; MRXSNA; Peripheral plasma membrane protein CASK; Protein lin-2 homolog; TNRC8; trinucleotide repeat containing 8
Gene Symbols: CASK
Molecular weight: 105,123 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein