PUS7 Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types. Belongs to the pseudouridine synthase TruD family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 5.4.99.-; Isomerase
Chromosomal Location of Human Ortholog: 5|5 A3
Cellular Component:  nucleus
Molecular Function:  enzyme binding; isomerase activity; pseudouridine synthase activity; RNA binding
Biological Process:  mRNA pseudouridine synthesis; negative regulation of translation; pseudouridine synthesis; regulation of hematopoietic stem cell differentiation; regulation of mesoderm development; RNA modification; tRNA processing; tRNA pseudouridine synthesis
Reference #:  Q91VU7 (UniProtKB)
Alt. Names/Synonyms: C330017I15Rik; mKIAA1897; MKIAA1897 protein; pseudouridylate synthase 7 homolog; pseudouridylate synthase 7 homolog (S. cerevisiae); Pus7
Gene Symbols: Pus7
Molecular weight: 74,793 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
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PUS7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene