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PUS7
Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types. Belongs to the pseudouridine synthase TruD family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 5.4.99.-; Isomerase |
| Chromosomal Location of Human Ortholog: 5|5 A3 |
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Cellular Component:
nucleus
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Molecular Function:
enzyme binding; isomerase activity; pseudouridine synthase activity; RNA binding
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Biological Process:
mRNA pseudouridine synthesis; negative regulation of translation; pseudouridine synthesis; regulation of hematopoietic stem cell differentiation; regulation of mesoderm development; RNA modification; tRNA processing; tRNA pseudouridine synthesis
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Reference #:
Q91VU7
(UniProtKB)
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Alt. Names/Synonyms: C330017I15Rik; Kiaa1897; mKIAA1897; MKIAA1897 protein; pseudouridylate synthase 7; pseudouridylate synthase 7 homolog; pseudouridylate synthase 7 homolog (S. cerevisiae); Pus7
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Gene Symbols: Pus7
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Molecular weight:
74,793 Da
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Basal Isoelectric point:
5.6
Predict pI for various phosphorylation states
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