PUS7 Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types. Belongs to the pseudouridine synthase TruD family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 5.4.99.-; Isomerase
Chromosomal Location of Human Ortholog: 7q22.3
Cellular Component:  nucleus
Molecular Function:  enzyme binding; pseudouridine synthase activity
Biological Process:  mRNA pseudouridine synthesis; negative regulation of translation; regulation of hematopoietic stem cell differentiation; regulation of mesoderm development; tRNA pseudouridine synthesis
Disease: Intellectual Developmental Disorder With Abnormal Behavior, Microcephaly, And Short Stature
Reference #:  Q96PZ0 (UniProtKB)
Alt. Names/Synonyms: FLJ20485; IDDABS; KIAA1897; MGC17720; pseudouridine synthase 7; pseudouridylate synthase 7 (putative); Pseudouridylate synthase 7 homolog; pseudouridylate synthase 7 homolog (S. cerevisiae); PUS7
Gene Symbols: PUS7
Molecular weight: 75,035 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
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PUS7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene