| COL4A3BP Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: ATYPICAL group; COL4A3BP family; EC 2.7.11.9; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical |
| Chromosomal Location of human Ortholog: 5q13.3 |
| Cellular Component: cytosol; endoplasmic reticulum membrane; Golgi apparatus; mitochondrion; nucleoplasm; perinuclear region of cytoplasm |
| Molecular Function: ceramide 1-phosphate binding; ceramide 1-phosphate transfer activity; ceramide binding; ceramide transfer activity; kinase activity; protein binding |
| Biological Process: cell morphogenesis; cell population proliferation; ceramide 1-phosphate transport; ceramide metabolic process; ceramide transport; endoplasmic reticulum organization; ER to Golgi ceramide transport; heart morphogenesis; immune response; in utero embryonic development; intermembrane lipid transfer; intermembrane sphingolipid transfer; lipid homeostasis; mitochondrion morphogenesis; muscle contraction; response to endoplasmic reticulum stress; signal transduction |
| Disease: Mental Retardation, Autosomal Dominant 34 |
| Reference #: Q9Y5P4 (UniProtKB) |
| Alt. Names/Synonyms: C43BP; Ceramide transfer protein; ceramide transporter; ceramide transporter 1; CERT; CERT1; CERTL; COL4A3BP; collagen type IV alpha 3 binding protein; Collagen type IV alpha-3-binding protein; collagen, type IV, alpha 3 (Goodpasture antigen) binding protein; FLJ20597; Goodpasture antigen-binding protein; GPBP; hCERT; lipid-transfer protein CERTL; MRD34; StAR-related lipid transfer (START) domain containing 11; StAR-related lipid transfer protein 11; STARD11; START domain containing 11; START domain-containing protein 11 |
| Gene Symbols: CERT1 |
| Molecular weight: 70,835 Da |
| Basal Isoelectric point: 5.29 Predict pI for various phosphorylation states |
| Select Structure to View Below |
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COL4A3BP |
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Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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Reactome
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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