CLSTN3 May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. According to PubMed:12498782, expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung. According to PubMed:12972431, predominant expression in brain, and only marginal in kidney. In brain, present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6|6 F2
Cellular Component:  cell surface; endoplasmic reticulum; GABA-ergic synapse; glutamatergic synapse; Golgi apparatus; integral component of membrane; integral component of postsynaptic density membrane; membrane; plasma membrane; postsynaptic density; postsynaptic membrane; protein-containing complex
Molecular Function:  calcium ion binding; protein binding
Biological Process:  cell adhesion; homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of protein localization to synapse; positive regulation of synapse assembly; positive regulation of synaptic transmission; regulation of cell growth; regulation of presynapse assembly; synapse assembly; synaptic transmission, GABAergic; synaptic transmission, glutamatergic
Reference #:  Q99JH7 (UniProtKB)
Alt. Names/Synonyms: Alc-beta; Alcadein-beta; calsyntenin 3; calsyntenin 3beta; Calsyntenin-3; Clstn3; Clstn3b; Cs3; CST; Cst-; Cst-3; Cstn3; mKIAA0726; OTTMUSP00000026175
Gene Symbols: Clstn3
Molecular weight: 105,872 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
Select Structure to View Below

CLSTN3

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene