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CLSTN3
May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. According to PubMed:12498782, expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung. According to PubMed:12972431, predominant expression in brain, and only marginal in kidney. In brain, present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of human Ortholog: 12p13.31 |
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Cellular Component:
cell surface; dendrite; endoplasmic reticulum membrane; GABA-ergic synapse; glutamatergic synapse; Golgi membrane; lipid droplet; postsynaptic density membrane; postsynaptic membrane; protein-containing complex
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Molecular Function:
amyloid-beta binding; calcium ion binding; cell-cell adhesion mediator activity; kinesin binding; neurexin family protein binding; protein binding; X11-like protein binding
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Biological Process:
homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of protein localization to synapse; positive regulation of synapse assembly; positive regulation of synaptic transmission; regulation of cell growth; regulation of presynapse assembly; synapse assembly; synaptic transmission, GABAergic; synaptic transmission, glutamatergic
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Reference #:
Q9BQT9
(UniProtKB)
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Alt. Names/Synonyms: Alc-beta; alcadein beta; Alcadein-beta; alcbeta; cadherin-related family member 14; calsyntenin 3; Calsyntenin-3; CDHR14; CLSTN3; CS3; CSTN3; KIAA0726; MGC131797; MGC138488
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Gene Symbols: CLSTN3
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Molecular weight:
106,098 Da
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Basal Isoelectric point:
5.24
Predict pI for various phosphorylation states
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