CLSTN3 May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. According to PubMed:12498782, expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung. According to PubMed:12972431, predominant expression in brain, and only marginal in kidney. In brain, present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of human Ortholog: 12p13.31
Cellular Component:  cell surface; dendrite; endoplasmic reticulum membrane; GABA-ergic synapse; glutamatergic synapse; Golgi membrane; postsynaptic density membrane; postsynaptic membrane; protein-containing complex
Molecular Function:  amyloid-beta binding; calcium ion binding; kinesin binding; protein binding; X11-like protein binding
Biological Process:  homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of protein localization to synapse; positive regulation of synapse assembly; positive regulation of synaptic transmission; regulation of cell growth; regulation of presynapse assembly; synapse assembly; synaptic transmission, GABAergic; synaptic transmission, glutamatergic
Reference #:  Q9BQT9 (UniProtKB)
Alt. Names/Synonyms: Alc-beta; alcadein beta; Alcadein-beta; alcbeta; cadherin-related family member 14; calsyntenin 3; Calsyntenin-3; CDHR14; CLSTN3; CS3; CSTN3; KIAA0726; MGC131797; MGC138488
Gene Symbols: CLSTN3
Molecular weight: 106,098 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB