CHSY1 Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. Belongs to the chondroitin N-acetylgalactosaminyltransferase family. Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Glycan Metabolism - chondroitin sulfate biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 7|7 C
Cellular Component:  extracellular region; Golgi apparatus; Golgi cisterna membrane; integral component of membrane; membrane
Molecular Function:  acetylgalactosaminyltransferase activity; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; metal ion binding; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity; transferase activity; transferase activity, transferring glycosyl groups
Biological Process:  bone morphogenesis; cartilage development; chondrocyte development; chondroitin sulfate biosynthetic process; negative regulation of ossification; positive regulation of smoothened signaling pathway; proximal/distal pattern formation; sulfation
Reference #:  Q6ZQ11 (UniProtKB)
Alt. Names/Synonyms: carbohydrate (chondroitin) synthase 1; Chondroitin glucuronyltransferase 1; Chondroitin sulfate synthase 1; Chondroitin synthase 1; CHSS1; ChSy-1; Chsy1; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1; Kiaa0990; mKIAA0990; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1; N-acetylgalactosaminyltransferase 1
Gene Symbols: Chsy1
Molecular weight: 91,383 Da
Basal Isoelectric point: 9.29  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene