CARD11 Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway. Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 7p22.2
Cellular Component:  CBM complex; cytoplasm; cytosol; immunological synapse; membrane raft; plasma membrane
Molecular Function:  CARD domain binding; guanylate kinase activity; protein binding; protein self-association
Biological Process:  B cell differentiation; B cell proliferation; CD4-positive, alpha-beta T cell proliferation; GDP metabolic process; GMP metabolic process; homeostasis of number of cells; I-kappaB kinase/NF-kappaB signaling; positive regulation of B cell proliferation; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-2 production; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell receptor signaling pathway; protein homooligomerization; regulation of apoptotic process; regulation of B cell differentiation; regulation of T cell differentiation; T cell costimulation; thymic T cell selection; TORC1 signaling
Disease: B-cell Expansion With Nfkb And T-cell Anergy; Immunodeficiency 11; Immunodeficiency 11b With Atopic Dermatitis
Reference #:  Q9BXL7 (UniProtKB)
Alt. Names/Synonyms: bcl10-interacting maguk protein 3; BENTA; BIMP3; CAR11; CARD-containing MAGUK protein 1; card-maguk protein 1; CARD11; Carma 1; CARMA1; caspase recruitment domain family member 11; caspase recruitment domain family, member 11; Caspase recruitment domain-containing protein 11; IMD11; IMD11A; MGC133069; PPBL
Gene Symbols: CARD11
Molecular weight: 133,284 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein