ATP6V1A Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. Belongs to the ATPase alpha/beta chains family. High expression in the skin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - oxidative phosphorylation; Hydrolase
Chromosomal Location of Human Ortholog: 16|16 B4
Cellular Component:  apical plasma membrane; cytoplasm; cytosol; microvillus; plasma membrane; proton-transporting V-type ATPase, V1 domain; vacuolar membrane
Molecular Function:  ATP binding; nucleotide binding; proton-transporting ATPase activity, rotational mechanism
Biological Process:  ATP hydrolysis coupled proton transport; ATP metabolic process; cellular iron ion homeostasis; cellular response to increased oxygen levels; ion transport
Reference #:  P50516 (UniProtKB)
Alt. Names/Synonyms: 70-kDa subunit; AI647066; Atp6a1; Atp6a2; Atp6v1a; Atp6v1a1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa, isoform 2; ATPase, H+ transporting, lysosomal 70kD, V1 subunit A, isoform 1; ATPase, H+ transporting, lysosomal V1 subunit A; ATPase, H+ transporting, V1 subunit A, isoform 1; ATPase, H+ transporting, V1 subunit A1; lysosomal 70kDa; OTTMUSP00000027535; OTTMUSP00000027536; V-ATPase 69 kDa subunit; V-ATPase subunit A; V-type proton ATPase catalytic subunit A; VA68; Vacuolar proton pump subunit alpha; VATA; VPP2
Gene Symbols: Atp6v1a
Molecular weight: 68,326 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene