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ARHGEF14
Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus. Isoform 5 activates CDC42. Isoform 3: Does not catalyze guanine nucleotide exchange on CDC42. Belongs to the MCF2 family. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, Rac/Rho; Oncoprotein |
| Chromosomal Location of mouse Ortholog: 8|8 A1.1 |
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Cellular Component:
cytoplasm; endomembrane system; extrinsic component of cytoplasmic side of plasma membrane; extrinsic component of membrane; lamellipodium; membrane; plasma membrane
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Molecular Function:
1-phosphatidylinositol binding; guanyl-nucleotide exchange factor activity; lipid binding; phosphatidylinositol binding; protein binding
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Biological Process:
intracellular signal transduction; positive regulation of Rho protein signal transduction; positive regulation of transcription by RNA polymerase II; Rho protein signal transduction
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Reference #:
Q64096
(UniProtKB)
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Alt. Names/Synonyms: ARHGEF14; C130040G20Rik; DBL's big sister; Dbs; exchange factor for RhoA and Cdc42; Guanine nucleotide exchange factor DBS; guanine nucleotide exchange factor OSTIII; mcf.2 transforming sequence-like; MCF2-transforming sequence-like protein; Mcf2l; mKIAA0362; Ost; Ost gamma
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Gene Symbols: Mcf2l
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Molecular weight:
129,113 Da
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Basal Isoelectric point:
5.62
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Microtubule Dynamics
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