ARHGEF14 Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus. Isoform 5 activates CDC42. Isoform 3: Does not catalyze guanine nucleotide exchange on CDC42. Belongs to the MCF2 family. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Oncoprotein
Chromosomal Location of Human Ortholog: 13q34
Cellular Component:  cytosol; endomembrane system; plasma membrane
Molecular Function:  phosphatidylinositol binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  G protein-coupled receptor signaling pathway; intracellular signal transduction; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction
Reference #:  O15068 (UniProtKB)
Alt. Names/Synonyms: ARHGEF14; DBL's big sister; DBS; FLJ12122; Guanine nucleotide exchange factor DBS; KIAA0362; MCF.2 cell line derived transforming sequence like; MCF.2 cell line derived transforming sequence-like; MCF2 transforming sequence-like protein; MCF2-transforming sequence-like protein; MCF2L; OST
Gene Symbols: MCF2L
Molecular weight: 128,109 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
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Protein Structure Not Found.

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