MKK3 Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 10q22
Cellular Component:  cytoplasm; cytosol
Molecular Function:  ATP binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein serine/threonine kinase activity
Biological Process:  activation of MAPK activity; activation of protein kinase activity; cardiac muscle contraction; cellular response to lipopolysaccharide; cellular response to sorbitol; cellular response to vascular endothelial growth factor stimulus; heart development; inflammatory response; MAPK cascade; p38MAPK cascade; positive regulation of blood vessel endothelial cell migration; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of transcription, DNA-templated; regulation of cytokine biosynthetic process; response to ischemia; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  XP_239239 (RefSeq)
Alt. Names/Synonyms: Map2k3; Map2k3 protein; mitogen activated protein kinase kinase 3
Gene Symbols: Map2k3
Molecular weight: 47,091 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Regulation of P38 MAPKs  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MKK3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene