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girdin
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome. Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin. Belongs to the CCDC88 family. Expressed ubiquitously. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding |
| Chromosomal Location of mouse Ortholog: 11|11 A3.3 |
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Cellular Component:
cell leading edge; cell projection; centriole; centrosome; ciliary basal body; COPI-coated Golgi to ER transport vesicle; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; endoplasmic reticulum; Golgi apparatus; lamellipodium; membrane; plasma membrane
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Molecular Function:
actin binding; dynein light intermediate chain binding; epidermal growth factor receptor binding; G-protein alpha-subunit binding; G-protein gamma-subunit binding; GDP-dissociation inhibitor activity; guanyl-nucleotide exchange factor activity; insulin receptor binding; microtubule binding; phosphatidylinositol binding; protein binding; protein homodimerization activity; protein kinase B binding; protein kinase C binding; SH2 domain binding; vascular endothelial growth factor receptor 2 binding
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Biological Process:
activation of protein kinase activity; activation of protein kinase B activity; cell migration; cell projection organization; cytoplasmic microtubule organization; cytoskeleton-dependent intracellular transport; DNA replication; lamellipodium assembly; maintenance of protein location in plasma membrane; membrane organization; nervous system development; positive regulation of cilium assembly; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of protein localization to cilium; positive regulation of stress fiber assembly; regulation of actin cytoskeleton organization; regulation of cell population proliferation; regulation of DNA replication; regulation of neuron projection development; regulation of protein phosphorylation; small GTPase mediated signal transduction; TOR signaling
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Reference #:
Q5SNZ0
(UniProtKB)
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Alt. Names/Synonyms: A430106J12Rik; AI848406; Akt phosphorylation enhancer; Akt-phosphorylation enhancer; APE; C130096N06Rik; C330012F17Rik; Ccdc88a; coiled coil domain containing 88A; Coiled-coil domain-containing protein 88A; D130005J21Rik; G alpha-interacting vesicle-associated protein; Girders of actin filament; Girdin; GIV; Grdn; HkR; HkRP1; Hook-related protein 1; Kiaa1212; OTTMUSP00000005499
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Gene Symbols: Ccdc88a
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Molecular weight:
215,918 Da
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Basal Isoelectric point:
5.92
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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