MARK1 a member of the CAMKL family of protein kinases. The MARK group of kinases is apparently involved in the control of cell polarity, microtubule stability and cancer. MARK1 forms a tight association with Tau in neurofibrillary tangles in Alzheimer disease tissue. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC 2.7.11.1; EC 2.7.11.26; Kinase, protein; MARK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1|1 H5
Cellular Component:  cell projection; cytoplasm; cytoskeleton; dendrite; membrane; plasma membrane
Molecular Function:  ATP binding; kinase activity; lipid binding; magnesium ion binding; metal ion binding; nucleotide binding; phosphatidic acid binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity; transferase activity
Biological Process:  cytoskeleton organization; establishment of cell polarity; establishment of mitochondrion localization; intracellular signal transduction; microtubule cytoskeleton organization; neuron migration; phosphorylation; protein phosphorylation; regulation of dendrite development; regulation of neuron projection development; Wnt signaling pathway
Reference #:  Q8VHJ5 (UniProtKB)
Alt. Names/Synonyms: AW491150; B930025N23Rik; ELKL motif serine-threonine protein kinase 3; ELKL motif serine/threonine-protein kinase 3; Emk3; Kiaa1477; MAP/microtubule affinity-regulating kinase 1; Mark1; mKIAA1477; Serine/threonine-protein kinase MARK1
Gene Symbols: Mark1
Molecular weight: 88,335 Da
Basal Isoelectric point: 9.44  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MARK1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein