HELZ May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. Belongs to the DNA2/NAM7 helicase family. Expressed predominantly in thymus and brain. Expression is down-regulated in 28 of 95 tested cancer cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.-; EC 3.6.4.-; Helicase; RNA-binding
Chromosomal Location of Human Ortholog: 11|11 E1
Cellular Component:  cytosol; nucleus; P granule
Molecular Function:  ATP binding; helicase activity; hydrolase activity; metal ion binding; nucleotide binding; protein binding; RNA binding
Biological Process:  posttranscriptional gene silencing by RNA
Reference #:  Q6DFV5 (UniProtKB)
Alt. Names/Synonyms: 3110078M01Rik; 9430093I07Rik; 9630002H22Rik; AI851979; DRHC; helicase with zinc finger domain; Helz; Kiaa0054; Probable helicase with zinc finger domain
Gene Symbols: Helz
Molecular weight: 219,880 Da
Basal Isoelectric point: 7.04  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene