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LRRK1
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; LRRK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group |
| Chromosomal Location of mouse Ortholog: 7|7 C |
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Cellular Component:
cytoplasm; cytosol; mitochondrion
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Molecular Function:
ATP binding; GTP binding; identical protein binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
bone resorption; negative regulation of metaphase/anaphase transition of meiotic cell cycle; negative regulation of peptidyl-tyrosine phosphorylation; osteoclast development; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of intracellular signal transduction; positive regulation of MAPK cascade; positive regulation of peptidyl-tyrosine phosphorylation; protein phosphorylation
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Reference #:
Q3UHC2
(UniProtKB)
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Alt. Names/Synonyms: AW319595; C230002E15Rik; D130026O16Rik; Kiaa1790; leucine-rich repeat kinase 1; Leucine-rich repeat serine/threonine-protein kinase 1; Lrrk1; MGC28646; mKIAA1790; OTTMUSP00000030034
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Gene Symbols: Lrrk1
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Molecular weight:
225,470 Da
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Basal Isoelectric point:
6.25
Predict pI for various phosphorylation states
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