LRRK1 Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; LRRK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of mouse Ortholog: 7|7 C
Cellular Component:  cytoplasm; cytosol; mitochondrion
Molecular Function:  ATP binding; GTP binding; identical protein binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  bone resorption; negative regulation of metaphase/anaphase transition of meiotic cell cycle; negative regulation of peptidyl-tyrosine phosphorylation; osteoclast development; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of intracellular signal transduction; positive regulation of MAPK cascade; positive regulation of peptidyl-tyrosine phosphorylation; protein phosphorylation
Reference #:  Q3UHC2 (UniProtKB)
Alt. Names/Synonyms: AW319595; C230002E15Rik; D130026O16Rik; Kiaa1790; leucine-rich repeat kinase 1; Leucine-rich repeat serine/threonine-protein kinase 1; Lrrk1; MGC28646; mKIAA1790; OTTMUSP00000030034
Gene Symbols: Lrrk1
Molecular weight: 225,470 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene