FAM175B Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage. Belongs to the FAM175 family. Abro1 subfamily. Detected in heart muscle (at protein level). Detected in heart and muscle, and at much lower levels in brain (PubMed:21195082). Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 7|7 F3
Cellular Component:  BRISC complex; cytoplasm; cytoskeleton; microtubule; nucleus
Molecular Function:  microtubule binding; polyubiquitin modification-dependent protein binding; protein binding
Biological Process:  attachment of spindle microtubules to kinetochore; cell cycle; cell division; cellular response to freezing; chromosome segregation; mitotic cell cycle; mitotic spindle assembly; negative regulation of apoptotic process; protein K63-linked deubiquitination; response to ischemia
Reference #:  Q3TCJ1 (UniProtKB)
Alt. Names/Synonyms: AA589499; Abraxas brother protein 1; Abraxas2; Abro1; ABRX2; AI853413; BRISC complex subunit; BRISC complex subunit Abraxas 2; BRISC complex subunit Abro1; C430003P19Rik; F175B; Fam175; Fam175b; family with sequence similarity 175, member B; Kiaa0157; Protein FAM175B
Gene Symbols: Fam175b
Molecular weight: 46,943 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
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FAM175B

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene