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IST1
ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST. Belongs to the IST1 family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Vesicle |
| Chromosomal Location of mouse Ortholog: 8|8 D3 |
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Cellular Component:
centrosome; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; Flemming body; intracellular membrane-bounded organelle; midbody; nucleus
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Molecular Function:
identical protein binding; MIT domain binding; protein binding; protein domain specific binding; protein-containing complex binding
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Biological Process:
abscission; cell cycle; cell division; collateral sprouting; cytoskeleton-dependent cytokinesis; establishment of protein localization; positive regulation of collateral sprouting; positive regulation of proteolysis; protein localization; protein transport; viral capsid secondary envelopment; viral release from host cell
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Reference #:
Q9CX00
(UniProtKB)
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Alt. Names/Synonyms: 2400003C14Rik; AW536298; increased sodium tolerance 1; increased sodium tolerance 1 homolog (yeast); Ist1; IST1 homolog; Kiaa0174; mKIAA0174; RIKEN cDNA 2400003C14 gene
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Gene Symbols: Ist1
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Molecular weight:
39,468 Da
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Basal Isoelectric point:
5.3
Predict pI for various phosphorylation states
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